Objective To evaluate the effect of transversus abdominis plane block (TAPB) combined with flurbiprofen axetil on postoperative analgesia and rapid recovery in patients undergoing laparoscopic radical resection of colorectal cancer. Methods A total of 75 patients undergoing laparoscopic radical resection of colorectal cancer surgery under general anesthesia, American Society of Anesthesiologists (ASA) grade Ⅰ or Ⅱ, were selected. According to the random number table method, they were divided into three groups (n=25): a control group (group C), a TAPB group (group T), and a TAPB combined with flurbiprofen extranate group (group TF). Group C received general anesthesia alone. Meanwhile, ultrasound‑guided bilateral TAPB was performed in group T after anesthesia induction, where 0.375% ropivacaine was given at 20 ml on each side. After anesthesia induction, group TF was subject to ultrasound‑guided bilateral TAPB, while flurbiprofen axetil was intravenously given at 1 mg/kg. For patients in the three groups, their general information, and the intraoperative consumption of propofol and remifentanil were recorded. Their Visual Analogue Scale (VAS) scores on postoperative 2, 6, 12 h and 24 h were recorded. The consumption of sufentanil, the first time of pressing the analgesic pump, the total times of effective pressing the analgesic pump, and the rate of rescue analgesia, the time to first off-bed activity, the first exhaust time, and the length of hospitalization stay were recorded within 24 h after surgery. Results Compared with group C, group T and group TF showed decreases in the intraoperative consumption of propofol and remifentanil, lowered VAS scores on postoperative 2, 6, 12 h and 24 h, extended first time of pressing the analgesic pump, as well as the consumption of sufentanil, the times of effective pressing the analgesic pump, the time to first off‑bed activity, the first exhaust time, and the length of hospitalization stay within 24 h after surgery (all P<0.05), with a reduced rescue analgesic rate in group TF (P<0.05). Compared with group T, group TF presented decreases in the intraoperative consumption of propofol and remifentanil, lowered VAS scores on postoperative 2, 6 h, and 12 h, extended first time of pressing the analgesic pump, the consumption of sufentanil within 24 h after surgery, the times of effective pressing the analgesic pump, the first off‑bed acitivity, and shortened first flatus time (all P<0.05). Conclusions TAPB combined with flurbiprofen axetil can reduce the consumption of opioids, significantly improve postoperative pain, and accelerate the rapid recovery of patients.