Abstract: Pain is difficult to cure
satisfactorily.The analgesic drugs in the past have
focused on preventing the transmission of action potentials from reaching the brain rather than pinpointing the springhead giving birth to pain:the receptor itself.But now it has mostly changed.Transient Receptor Potential (TRP) channels have been implicated in several physiological processes.Transient Receptor Potential vanilloid 1(TRPV1) is one of the family of the TRPs.In recent years,compelling data has been gathered on the role of this channel in inflammatory and neuropathic states.The agonist and antagonist of it interrupt the generation and transmission to achieve the purpose of analgesia.
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