At present, the number of the patients with coronary heart disease who need operation is increasing every year in China, the primary cause of death in these patients is the happening of adverse cardiac events during perioperative period. Hypoxia is the important pathophysiological factor to induce the adverse cardiac events. As a regulation center of gene expression and recovery intracellular homeostasis of hypoxia-related genes, induce angiogenesis, vascular smooth muscle relaxation in hypoxia response, HIF can express, and regulate the expression of a series and contraction stabily, and induce angiogenesis, vascular smooth muscle relaxation and contraction, inhibition of platelet aggregation, red cell hyperplasia and the progression of coronary atherosclerosis, so it is likely to be the most promising and effective treatment for coronary artery disease.