【Abstract】Objective: To observe the effect of dexmedetomidine (DEX) on the quality of anaesthesia recovery in patients undergoing retroperitoneal laparoscopy. Methods: Forty American Society of Anesthesiologists (ASA)I-II patients were randomised assigned to two groups. Group D received DEX 0.5μg·kg-1 as bolus before induction and 0.4μg·kg-1·h-1 by infusion. Group C received equal volume of normal saline as Group D intravenously without DEX．All other induction and maintenance drugs were same in two groups. All patients were sent to PACU after operation, HR, MAP, and SPO2 of each patients before anesthesia(T0) and when they arrived PACU(T1), opened eyes(T2), extubate(T3) and leave PACU(T4) were recorded．The numbers of patients who have nausea and vomiting or shivering during anaesthesia recovery were also recorded.Results: Time of extubation and postanesthesia care unit discharge time were similar in both groups. While compared with T0, MAP of Group D did not change significantly at T2 and T3, but MAP of Group C increased. The number of patient who have nausea and vomiting or shivering were significantly higher in Group C while compared with Group D（30% vs 0%, 40% vs 10%）.Conclusion: DEX did not prolong the Time of extubation and postanesthesia care unit discharge time, at the same time can decrease the incidence of nausea and vomiting or shivering during anaesthesia recovery.