背景 随着对心肌缺血预处理（ischemic preconditioning, IPC）研究的不断深入，作为心肌IPC细胞内信号转导途径的一种“终末效应子”ATP敏感性钾离子通道（ATP-sensitive potassium channel, KATP通道）在IPC中的重要作用也越来越被广泛关注。 目的 进一步阐明心肌IPC的病理生理机制，为临床工作提供理论依据。 内容 对细胞膜KATP通道（sarcolemmal ATP-sensitive potassium channel, sarcKATP通道）的生理特性、在心肌IPC中的作用及其调节机制等研究进展进行综述。 趋向 以调节sarcKATP通道为靶点的研究有望为IPC策略研究提供新的思路。
Background In recent years, ischemic preconditioning(IPC) has been widely stuided. The ATP-sensitive potassium channel(KATP), which acts as a key "end-effector" in the pathways of intracellular signaling transduction, has gained wide attention because of its important role in the IPC. Objective To further clarify the pathophysiology of the IPC and provide theoretical basis for clinical work. Content This article reviews the research progress of the sarcolemmal ATP-sensitive potassium channel (sarcKATP) as well as its role in myocardial IPC. This article reviews the physiological characteristics of the sarcolemmal ATP-sensitive potassium channels (sarcKATP) channel, its role in myocardial IPC as well as its regulatory mechanism. Trend Regulating sarcKATP-targeted study is promising candidate for IPC.
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