国际麻醉学与复苏杂志   2018, Issue (5): 14-14
    
心脏α1受体的作用及在心衰中的应用进展
卜心怡, 葛亚力1()
1.南京医科大学附属南京医院(南京市第一医院)麻醉科
The role of cardiac α1 receptors and its application in heart failure
 全文:
摘要:

背景 在正常情况下,心脏α1受体所占比例较β受体少,但在心衰时,α1受体表达上调。大量细胞培养和动物模型证实,心脏α1受体具有重要的适应性作用。 目的 综述心脏α1受体的作用及在心衰中的应用进展。 内容 从α1受体在心脏中的表达、功能及在心衰中的应用进展3个方面进行综述。 趋向 更好地了解心脏α1受体的作用,为临床心功能不全治疗提供新的策略。

关键词: 肾上腺素受体; 心力衰竭
Abstract:

Background There are far fewer α1 receptors than β receptors in the non-failing heart, but the abundance of α1 receptors is increased in heart failure. Evidences from decades of studies in isolated cardiac myocytes and numerous animal models demonstrate important adaptive functions for cardiac α1 receptors. Objective To review the role of cardiac α1 receptors and its application in heart failure. Content This review will introduce heart α1 receptors from three aspects: the expression and function of α1 receptors in the heart, its application in heart failure. Trend To better understand the significance of cardiac α1 receptors and make better guidelines for cardiac malfunction administration.

Key words: Adrenergic receptor; Heart failure