Abstract: Objective To investigate the occurrence of rebound pain after peripheral nerve block (PNB) and its effect on postoperative clinical outcomes. Methods A total of 225 patients who underwent surgery with PNB in hospitals were selected as subjects. Among them, 83 patients were from Fengqiu Huageng Hospital, 77 from Huixian People's Hospital, and 65 from Henan Hongli Hospital. According to the presence of rebound pain after surgery, the patients were divided into two groups: a rebound pain group and a non-rebound pain group. Both groups were compared for general information. Then, logistic regression analysis was conducted to explore the related factors affecting postoperative rebound pain and postoperative clinical outcomes. Results Rebound pain occurred in 109 of 225 patients, with a rebound pain rate of 48.44%. The age of rebound pain group was older than that of non-rebound pain group (P<0.05), moderate and severe pain scores were obtained 1 day before operation, the rate of orthopedic operation and the rate of readmission 30 d after operation were higher than non-rebound pain group (all P<0.05), the use rate of dexamethasone, the rate of satisfaction with operation and the rate of choosing PNB again were lower than non-rebound pain group (all P<0.05). Old age [odds ratio (OR) 1.46 (95% confidence interval (CI) 1.14, 1.87), P=0.003], female [OR 1.18 (95%CI 1.00, 1.39), P=0.047], orthopedic surgery [OR 1.99 (95%CI 1.37, 2.90), P<0.001] were risk factors for postoperative rebound pain, and postoperative dexamethasone-assisted analgesia [OR 0.78 (95%CI 0.65, 0.94), P=0.008] was a protective factor for postoperative rebound pain. Compared with non-rebound pain, rebound pain was a risk factor for patients who were unsatisfied with surgery [OR 1.77 (95%CI 1.30, 2.41), P<0.001], readmission to hospital at postoperative 30 days [OR 1.37 (95%CI 1.11, 1.69), P=0.003], and not choosing PNB again [OR 2.04 (95%CI 1.38, 3.01), P<0.001]. Conclusion Clinicians should pay more attention to old and female patients, in an effort to prevent the occurrence of rebound pain.
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