Caveolae-mediated albumin transcytosis plays an important role in physiological and pathological conditions. The events initiating transcytosis have been shown to be tightly regulated by non-receptor type Src family kinases, and thus Src signaling is thought to be a critical “switch”regulating caveolae-mediated transcellular transport of the plasma protein albumin. The activation of Src induces phosphorylation of glycoprotein 60, caveolin-1 and dynamin-2, and initiates transcytosis. In response to inflammatory stimuli, neutrophil adhesion to vascular endothelial cells via ICAM-1（Intercellular adhesion molecule-1）cause Src activation which enhances caveolae transcytosis of albumin.