国际麻醉学与复苏杂志   2010, Issue (1): 80-82
    
替普瑞酮对组织器官的保护作用
沈爱玲 尚游 袁世荧 姚尚龙1()
1.武汉,华中科技大学同济医学院协和医院麻醉科
The protection of Geranylgeranylacetone on tissues and organs
 全文:
摘要:

替普瑞酮是一种临床抗溃疡药,也是热休克蛋白(heat shock proteins,HSPs)的诱导剂之一。多种伤害性应激因素,如缺血、缺氧、氧化、毒性等刺激时,替普瑞酮可增加各组织器官HSPs 的表达,保护组织器官的结构和功能。现就近年来关于替普瑞酮与组织器官保护作用的研究作如下综述。

关键词: 替普瑞酮;热休克蛋白;槲皮素
Abstract:

Geranylgeranylacetone is a clinical anti-ulcer drug. As a inducer of heat shock proteins,it could enhance HSPs expression in various tissues and organs,protecting their struction and fuction after stress,such as ischemia,anoxia,oxidation, toxin and et al. This article will review the protective effect of geranylgeranylacetone on tissues and organs.

Key words: Geranylgeranylacetone;Heat Shock Peoteins;Quercetin