Objective To assess and safety and efficacy of the wireless analgesic pump system. Methods 144 patients (ASAI-II)， received postoperative patient-controlled vein analgesia(PCIA)for 48 h, were randomly divided into two groups: the test group(n=72), using the wireless analgesic pumps system,and the control group(n=72), using type ZZB analgesic pump.The settings were as follows:loading does 5 ml,background infusion 2.5 ml/h, bolus 3ml, lockout time 8 min,and the prescription were as follows:fentanyl 12 μg•kg-1•d-1，droperidol 5 mg Admixed with NS to reach 150 ml. Outcome measures: ① Age, weight, sex, and preoperative T, Hr, RR, BP. ②pain rating when using PCIA for 4h, 24h, 48h. ③ the number of all attempts. ④the number of successfully delivery. ⑤shivering, fever, nausea, vomiting, respiratory depression and other adverse adverse effect in early phase. Results 144 patients underwent thoracic，urology, orthopedics, and general surgery. NO differences in age, weight, sex, and preoperative T, Hr, RR, BP were found between two groups (P>0.05). The pain rating NRS are 1.3±1.4, 1.6±1.5 and 1.3±1.4 in test group and 1.3±1.3, 2.1±1.8 and 1.7±1.7 in control group at 4,14,48 h.. There were no difference between two groups (P>0.05). The number of all attempts is 6±10 in test group and 5±13 in control group, the number of successfully delivery is 2±4 in test group and 3±6 in control group during 48 h, which were no difference between two groups (P>0.05). Patients did not have any adverse effcet in early phase. Conclusion The wireless analgesic pump and its management system were safe for individual treating a variety of acute or chronic pain and other treatment requiring continuing or intermittent injection to maintain a certain plasma concentration.