Summary Ischemic postconditioning alleviating ischemia reperfusion injury had been confirmed by experimental study and clinical study,the mechanism was relevantd to enhancing organization antioxidant capacity and Inhibiting apoptosis.However,in recent years,it had putted forward that mitochondrial permeability transition pore play a important role in ischemic postconditioning alleviating ischemia reperfusion injury, This review will discuss the mechanisms of ischemic postconditioning from Mitochondrial permeability transition pore.Purpose It elaborates the role of MPTP in IPo organs protection mechanism.Content Mitochondrial permeability transition pore,(MPTP)is identified as the final targets of ischemic postconditioning.It is a kind of composite protein channel located inside and outside on the mitochondrial membranes, which’s open induced intracellular calcium overload,the mitochondrial membrane potential reduced,reactive oxygen species increased, pro-apoptotic proteins released.IPo attenuates reperfusion injury by several signal transduction pathways, and regulation of Mitochondrial permeability transition pore is an important aspect.Trend The MPTP research perfect the IPo organs protection mechanism.