脑出血是临床上的常见疾病如血管畸形、动脉瘤、高血压、肿瘤所引起 ,占全部脑血管病的 35 %左右 ,病死率高达 50 %以上 ,是威胁中老年人健康的主要疾病之一，其可引起多种继发病变如:脑水肿、颅内压增高、脑疝等 ,其中脑水肿的产生是脑出血后导致ICH病情恶化的关键因素，主要表现为脑组织中异常水分储留使脑容积增加 ,导致颅内高压 ,直接威胁病人生命及预后。如何抑制或减轻脑水肿的发生、发展是目前实验研究的重点。水通道蛋白（AQP）是近年来发现的与水通透性有关的细胞膜转运蛋白[2],其主要影响水跨膜转运和细胞内外环境平衡调节。AQP4在多种神经系统疾病中导致脑水肿的形成过程中起到了关键的作用,同时脑出血后使得血肿周围脑组织氧化抗氧化平衡紊乱及自由基反应病理性加剧。本文就脑水肿形成机制以及和AQP4、氧自由基研究进展综述如下。
Cerebral edema is the abnormal brain tissue water retention and the brain volume increase is associated with many diseases a pathological state. Aquaporin (AQP) are membrane water channel protein family, to regulate the water balance across cell selective channels, including aquaporin 4 (AQP4) in the nervous system is the most abundant, and the nervous system, physiological and pathological processes, especially water Metabolism is closely related to acute cerebral hemorrhage while perihematoma oxidation and free radical oxidation disorders in response to further increase the pathological increase of cerebral edema, this article will AQP4 and oxygen free radicals in cerebral edema and the machine made a brief overview.
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