Objective To study the effects of nocuous stimulation onα2-band of QPEEG in rabbits. Methods Rabbits of both sexes were randomly divided into 3 groups(n=9): mopping group(group M); forceps holder group(group H); cutting group(group C). According to it ,different stimulation were given to the rabbits which had been injected muscle relaxant by vein . The EEG sample was obtained before and at some intervals following the stimulation given to . The EEG activity was processed with the power spectral analysis. Results The percentage ofα2-band power showed no significant changes in group M(P>0.05); the percentage ofα2-band power were increased(P<0.05) in group H within 30s~60s after received stimulation in all the areas; the percentage ofα2-band power in group C increased significantly in all areas of brain(P<0.05). The changes lasted for 2min. Conclusion After given nocuous stimulation, the percentage ofα2-band power increased, which showed that the percentage ofα2-band power would be an effective means of monitoring pain.