Objective: To investigate the effects of acute hypervolumic hemodilution(AHH) with 6% hydroxyethyl starch（130/0.4）on glycometabolism in patients with posterior lumbar decompression and bone graft-fixation. Methods: Sixty ASA I~II patients scheduled for elective surgery were randomly divided into three groups: control group (groupA，n=20), Ringer's solution group (groupB，n=20) and voluven group (groupC，n=20)．In group B and C，15 ml•kg-1 Ringer's solution or voluven were infused respectively in 20~30min after induction of anesthesia. HR, MAP, SPO2 and CVP were continuously monitored in three groups. Blood samples were taken and the level of Hb, Hct, glucose(glu), cortisol(cor), glucone (gln) and insulin( ins) were examined at different time points: prior to the AHH (T1), AHH finished immediately (T2), after surgery (T3),and 2 hours after surgery (T4). Also the HOMA-insulin resistance index (HOMA-IRI) and insulin sensitivity index (ISI) were calculated. Results: The hemodynamics of B and C groups remained stable at T2 compared with that before T1, but the level of glu, cor, gln and ins declined. At T3 and T4 in group A and B Hb, Hct and ISI significantly decreased (p<0.05). Glu, cor, gln, ins and IRI increased markedly (p<0.05). There were significant changes of glu, cor, gln, ins, IRI and ISI at T1. At T3 and T4 in group C , glu、cor、gln、ins and IRI elevated to a lesser degree than that observed in group A and B．there was no significant changes of glu, cor, gln, ins, IRI and ISI when compared with that of T1. Conclusions：.Implemented AHH with voluven before surgery can reduce posterior lumbar decompression and bone graft in patients with the concentration of stress hyperglycemia, cortisol, glucone and insulin resistance.