国际麻醉学与复苏杂志   2012, Issue (5): 6-6
    
急性肺损伤/急性呼吸窘迫综合症液体治疗策略
何征宇, 王祥瑞1()
1.上海交通大学医学院附属仁济医院
The Fluid Therapy Strategy for Acute Lung Injury and Acute Respiratory Distress Syndrome
 全文:
摘要:

【背景】 高通透性肺水肿是ALI/ARDS的基本病理生理特征,其程度与ALI/ARDS的预后密切相关。 【目的】对ALI/ARDS患者合理的液体管理,有助于改善ALI/ARDS患者的肺水肿,降低该病病死率。 【内容】 本文回顾了ALI/ARDS液体治疗策略探索过程中存在争议的问题(如限制性或开放性的液体治疗策略及治疗液体种类的选择),总结了该领域近年来的研究进展(如ALI/ARDS病程不同阶段的差异化治疗及液体治疗的监测指标)。 【趋向】 今后将进一步探索该病在不同的病理生理状态下特异性的液体治疗方法,寻求高效敏感的监测指标,指导液体治疗策略的选择和调整。

关键词: 急性肺损伤,急性呼吸窘迫综合症,液体治疗
Abstract:

[Background] High permeability pulmonary edema is the basic pathophysiological characteristics of acute lung injury and acute respiratory distress syndrome (ALI/ARDS), the degree of which is directly bound up with the prognosis of ALI/ARDS. [Objective] Rational fluid therapy for ALI/ARDS patients contributes to pulmonary edema amelioration and mortality reduction. [Content] In this article, we reviewed the controversial issues such as(1)the selection of a conservative or a liberal strategy of fluid therapy and(2)the selection of the fluid type. We also summarized the research progress in this field, such as (1)different treatment and(2) monitoring indicators for distinct stage in the progress of ALI/ARDS during the past few years. [Trend] Future research will focus on exploring specific fluid therapy strategy for ALI/ARDS during various pathophysiology stages, and seeking effective and sensitive monitoring indicators to guide the selection and adjustment of fluid therapy strategy for ALI/ARDS.

Key words: acute lung injury,acute respiratory distress syndrome,fluid therapy