背景 近年的研究显示γ-氨基丁酸(γ-aminobutyric acid，GABA)-GABAA受体通路与神经发生有密切联系。神经发生不仅存在于胎儿期和新生儿期，同时还存在于成年期。大脑海马区的神经发生状态与认知和学习记忆功能成正比。目的 通过阐述GABAA受体和神经发生的关系，进而探讨与GABAA受体密切相关的全身麻醉药物的临床药理。内容 这篇综述主要关注GABAA受体、神经发生和认知功能之间的关系及其介导机制。趋向 系统的研究GABAA受体和神经发生关系将为全身麻醉药对认知功能影响的研究提供新的思路。
Background Recent researches have revealed the intimate relationship between γ-aminobutyric acid （GABA）-GABAA receptors pathway and neurogenesis. Neurogenesis occurs not only in fetal and neonatal period but in adult. The neurogenesis in hippocampus has an intimate relationship with cognitive function and memory. Objective To investigate the relationship between the GABAA receptors and the neurogenesis, explore the pharmacology of general anesthetics works through the GABAA. Content This review is mainly focused on the relationship between the GABAA receptors and the neurogenesis and the underlying mechanism. Trend Systematic studies focused on the relationship between the GABAA receptors and the neurogenesis will provide new ideas regarding the studies of the effects of general anesthetic on the cognitive function.
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