[Abstract]Objective To investigate the effect of Laryngeal mask airway and nasotracheal intubation airway on intraoperative wake-up test in patients during operation on cerebral cortical functional area under propofol-remifentanil anesthesia administered by TCI Methods twenty ASA I or II neurosurgical patients undergoing operation on cerebral cortical functional area were divided into two groups (n=10 each).We defined group I as the patients with lesions in the language centre and lesion both in the language centre and motive centre, group II as the patients with lesions in the motive centre. Anesthesia was induced and maintained with propofol-remifentanil by TCI both group I and group II. In group I, LMA was given when the patients at the situation of sedation. In group II, the patients were given nasotracheal intubation at the situation of sedation . We carried on wake-up test during the operation ,and defined the duration from interruption of anesthesia to the moment when the patients responding to commands as the wake-up time, then recorded the variables of MAP,HR,PETCO2 in the timepoint of anesthesia induced(T1),10 minutes after intubation(T2),wake-up time (T3),and recorded the corresponding target plasma concentration of propofol and remifentanil in different time, adverse events during wake-up test were also recorded meanwhile. Result All patients were underwent wake-up test and operation successfully. Two groups wake-up times were not significantly changed (P>0.05);the incidence of vomiting, hypercopmia and brain swelling of group II were lower than of group I significantly (p<0.05). Conclusion For the patients with lesions in the cerebral cortical motive centre, using nasotracheal intubation airway can increase the effect of wake-up test with propofol and remifentail administered by TCI.