[Abstract]Objective To study the effect of different resuscitation fluids on cardiac function of the heat shock injury rabbits. Methods 40 rabbits were randomly divided into four groups, groupⅠ: control group (without thermal injury), groupⅡ: 0.9% NaCl injection, group Ⅲ: lactated Ringer's injection, group Ⅳ: compound electrolyte injection. The infusion rate was 0.33 ml / kg /%(area percentage of heat injury)/h in 4 h when the thermal injury of rabbit body surface area was 25% to 30%. To measure and record the parameters of cardiac function in each group by working heart preparation in vitro model. Results The parameters of CO, dp/dt, -dp/dt in groupⅡ were significantly lower than in groupⅠ(P <0.05, P <0.01), these parameters can be improved in group Ⅲ, but can not be returned to the appropriate levels in groupⅠ. The parameters in group Ⅳ were close to the levels in groupⅠ(P>0.05). Stroke work and aortic peak systolic pressure in group Ⅱwere significantly lower than in group Ⅰ (P <0.05, P <0.01), group Ⅲ and Ⅳ had no significant difference with group Ⅰ.Conclusions To infuse compound electrolyte injection is more conducive to improve the tissue oxygen supply, maintain effective circulating blood volume, improve cardiac function and compliance in severe thermal injury in hypovolemic shock, it can replace lactated Ringer's injection.