目的 探讨心脏雌激素预处理后对氯胺酮心脏抑制是否具有保护作用。 方法 将21只蟾蜍采用随机数字表法随机分成3组(每组7只)，分别将氯胺酮（0.015 mol/L）、雌激素（2.5×10-5mol/L）滴加一滴于离体蛙心的灌流液中，观察以上药物对蛙心收缩力的影响，并观察雌激素预处理后，再滴加氯胺酮后心肌收缩力的变化。 结果 氯胺酮可抑制心脏，降低心肌收缩力（3.1±1.0）g (P＜0.05)；雌激素可增强心肌收缩力（5.9±2.4）g (P＜0.05)；雌激素预处理后氯胺酮心脏抑制作用减弱（5.6±2.3）g（P＜0.05）。 结论 雌激素预处理对氯胺酮心脏抑制具有保护性作用。
Objective To observe if estrogen preconditioning have the protective effect on myocardial depression by ketamine. Methods 21 toads were assighed into 3 groups randomly and a drop of ketamine(0.015 mol/L) and estrogen(2.5×10-5mol/L) were put into perfusate of the isolated frog heart to observe the effect of the drugs on the contraction force of frog heart , and to observe the change of the contraction force of frog heart after estrogen preconditioning. Results Ketamine can cause myocardial depression and reduce myocardial contraction（3.1±1.0）g (P＜0.05), estrogen can strengthen myocardial contraction（5.9±2.4） g (P＜0.05), the myocardial depression induced by ketamine was weakened by estrogen preconditioning（5.6±2.3）g (P＜0.05). Conclusions Estrogen preconditioning show protective effect on myocardial depression induced by ketamine
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