Objective The aim of this study was to observe analgesic effect and safety with flurbiprofen axietil, tramadol, ketamine anesthesia in children after tonsillectomy and adenoidectomy, as well as to find suitable drugs for short operation preemptive analgesia in children to reduce the agitation after general anesthesia and postoperative pain in pediatric patients. Methods In this study, eighty patients（4 to 14 years old ）scheduled for tonsillectomy and adenoidectomy were randomly divided into four groups ( n = 20). Group F received preoperative intravenous administration of flurbiprofen axietil 1 mg/kg at 10 min before surgery. Group K received preoperative intravenous administration of ketamine 0.5 mg/kg at 10 min before surgery. Group T received preoperative intravenous administration of tramadol 2 mg/kg at 10 min before surgery. Group C received preoperative intravenous administration 3 ml saline at 10 min before surgery. Observed VAS score, restlessness scores, MOPS score, BP and HR, RR and VT, oxygen saturation and adverse reactions. Results Restlessness scores in thw group F, the group K and the group T were significiantly lower than in the group C. VAS score and MOPS scores in the group F ( 0.65±0.99 and 0.80±1.01)、the group K （1.85 ±1.87 and 1.80±1.70）、the group T （0.75±1.37 and 0.75±1.33）at 0 hours after operation were significantly lower than in the group C （3.70±1.66 and 3.50±1.47) (P<0.01); at 8 hours after operation, VAS score in the group F (0.88±0.99 ) was significantly lower than in the group C （1.68±0.73）, the group K （1.75±1.71） and the group T （1.78±0.72） (P < 0.01); MOPS score in the group F （0.30±0.66）was lower than in the group C (0.70±0.57) (P<0.05) at 8 hours after operation; VAS score in the group F and the group T was lower than in the Group K(P<0.05) at 0 hours after operation. BP and HR, RR and VT, oxygen saturation changes in all four groups are in the normal range. Blood pressure in the group F was significantly lower than in the group K, the group T and the group C at 0 hours after operation (P < 0.01). No arrhythmia, respiratory inhibition, coagulant function abnormality were found in four groups. There was no statistical significance between four groups in Nausea, vomiting, dizziness, agitated, nightmares, abdominal pain and other adverse reaction. The incidence of postoperative poor sleep in the group C was higher than in the group F (P<0.05). Conclusions Flurbiprofen axietil, ketamine, tramadol effectively reduced restlessness during recovery. Ketamine and tramadol showed no effect of preemptive analgesia. Flurbiprofen axietil effectively relieved postoperative pain in children. Flurbiprofen axietil can be safely used for postoperative analgesia in children during minor surgery.