国际麻醉学与复苏杂志   2012, Issue (10): 1-1
    
沉默信息调节蛋白1蛋白在心肌缺血/再灌注中的保护作用
刘玲, 刘新伟1()
1.重庆医科大学附属第一医院
The protective role of silent information regulator protein 1 in myocardial ischemia reperfusion injury
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摘要：

背景 沉默信息调节蛋白1（silent information regulator protein 1，Sirt1）是尼克酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide，NAD）依赖的第3类组蛋白/非组蛋白去乙酰酶，参与细胞内多种生物功能的调节。Sirt1不仅在抗衰老中发挥重要作用，同样在心肌缺血/再灌注（ischemia /reperfusion, I/R）时保护受损细胞。目的 对Sirt1在心肌I/R中的保护机制以及几种激活Sirt1活性的方法进行综述。内容 Sirt1能使活性氧清除剂产生增加、抗心肌细胞凋亡、促进细胞内自噬、减轻炎症反应、促进胞内正常线粒体合成等而减轻I/R的心肌细胞损伤。通过多种方法提高I/R时Sirt1的活性，是减轻损伤的重要措施。趋向 随着Sirt1在心肌I/R中的作用机制不断被揭示，其将成为缓解心肌I/R损伤的重要靶点。
关键词： 沉默信息调节蛋白1；缺血/再灌注损伤；活性氧；细胞凋亡；自噬
Abstract:

Background Silent information regulator protein 1(Sirt1) is a NAD-depended class III histone/nonhistone deaceytalase, which regulates various biological processes. Not only does Sirt1 play an important role in anti-aging, it also protects cardiomyocytes from ischemia and reperfusion（I/R）injury. Objective To review the mechanisms of Sirt1’s protecting cardiomyocytes from myocardial I/R injury and several ways to activating sirt1. Content Sirt1 alleviates the I/R injury by increasing the generation of reactive oxygen species scavengers, inhibiting the apoptosis, promoting autophagic flux, attenuating the inflammatory reactions and promoting mitochondrial biogenesis. Activating Sirt1 is an important method in attenuating the I/R injury. Trend Sirt1 will be one of key targets in alleviating the I/R injury as the research about its protective mechanism is deepening.
Key words: Silent information regulator protein 1；Ischemia/ reperfusion injury；Reactive oxygen species；Apoptosis；Autophagy