Objective To evluate effects on recovery quality of different doses of sufentanil combined with propofol and remifentanil by TCI for patients in laparoscopic cholecysteetomy .Methods One thoudred and fifty patients scheduled for laparoscopic cholecysteetomy were divided into 5 groups randomly according to random digits table（n=30): sufentanil 0.1 ug/kg (group F1), 0.2 ug/kg (group F2), 0.3 ug/kg (group F3), 0.4 ug/kg (group F4), the same dose N.S (group N).ECG,BP,HR,SpO2 and PETCO2 were monitored during the operation.Anesthsia was induced and maintained with propofol and remifentanil by TCI in all patients. 10 min before the end of operation, different doses of sufentanil were given through vein to the correspond groups while group N was given the same dose of N.S. Mean arterial pressure (MAP) , heart rate (HR) were measured 0 min (T0), 10 min (T1) after surgery, 1 min before extubation(T2) , 0 min (T3),5 min (T4) , 10 min (T5) after extubation. Extubation time, the recovery of spontaneous breathing time, recovery time were measured, visual analogue scale (VAS) was recorded 10,30, 60 min and 4 h after extubation.The complications of anesthesia were observed and recorded during recovery, including restlessness, respiratory depression and lethargy, et al .Results Compared with T0, MAP, HR increased in group N and group F1 at T1 -5 (P <0.05). Compared with group N and group F1 respectively, group F2 ,group F3 and group F4 have lower MAP, HR (P <0.05). Extubation time, the recovery of spontaneous breathing time and recovery time were longer in group F3 and group F4 (P < 0.05). Postoperative early VAS scores were lower in group F2 ,group F3 and group F4(P < 0.05). The complications were less in group F2.Conclusions Sufentanil 0.2 ug/kg given through vein 10 min before he end of operation is the dose of choice for patients undergoing laparoscopic cholecysteetomy with total intravenous anesthesia and might ameliorate recovery quality effectively.