Objective To compare the effects of infusing Sodium Potassium Magnesium Calcium and Glucose Injection, Ringers solution and Lactated Ringers solution on acid-base balance during operation. Methods 48 patients undergoing radical gastrectomy were divided equally into 3 groups randomly(n=16): the lactated Ringers group(group L), the Ringers solution group(group N) and Sodium potassium magnesium calcium and glucose injection group(group A). The lactated Ringers solution was given in group L and the Ringers solution in group N, Sodium potassium magnesium calcium and glucose injection was given in group A. Neither groups are cross-given other crystal solution during potation, Voluven was the colloid solution in both groups. Changes of lactate and gas before and 1, 2, 3, 4 h after induction respectively were observed. Results There was no statistics difference in the age, sex, stature, weight, ASA grade, operation time, anesthesia time, the volume of transfusion during operation, hemorrhage and urine volume etc of both groups(P>0.05). The glucose level increased significantly 60 min after anesthesia in both groups, but there was no statistics difference between the three groups(P>0.05). Calcium concentration in group A increased by 14.30, 9.43, 9.84, 10.92% at time point of T1, T2, T3, T4 respectively compared to group L(P<0.05). Calcium concentration in group A increased by 12.86, 8.53, 6.26% at time point of T1, T2, T3 respectively compared to group N(P<0.05). Serum lactate level increased 33.3% at T2 compared to T0 time point in Group L(P<0.05). Conclusions Sodium Potassium Magnesium Calcium and Glucose solution does not increase serum lactate level in gastrectomy. We found this solution had benefits in maintaining serum calcium level.