Backgroud Histone deacetylase inhibitors( HDACI) received attention because of its outstanding protection role in the early parmacological resuscitation of shock. Purpose To review the clinical application and classification of HDACI, and discusse its advantages and mechanisms as a drug for hemorrhagic shock and septic shock. Content HDACI is promising to early survival of shock through its anti- apoptosis effect and many other mechanisms, offers considerable protection in the hemorrhagic shock and septic shock model. Trend HDACI is a new stratege for aproving early survival, at the same time provide potential new clinical applications of shock in the future.