国际麻醉学与复苏杂志   2012, Issue (9): 7-7
    
预测无痛人工流产术中发生体动反应的多因素logistic回归分析
姜黎珊, 张冯江, 马雷雷, 孙凯, 严敏1()
1.徐州医学院
Predicting body movement during induced abortion with intravenous anesthesia by multivariate logistic analysis
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摘要:

目的 通过对无痛人工流产术中体动反应进行多因素的回归分析,探讨灌注指数在静脉麻醉中预测体动反应的作用。方法 68例美国麻醉医师协会(ASA)分级 I级、年龄20岁~30岁、体重45 kg~60 kg接受无痛人工流产术的孕妇,麻醉给予异丙酚1.8 mg/kg和氯胺酮0.5 mg/kg静脉注射,患者安静3 min后的测量值(T1)作为基础值,给药后3 min时(T2)的测量值作为麻醉诱导后的值,记录这两个时刻的末梢灌注指数(perfusion index, PI)、脑电双频指数(bispectral index, BIS)、心率(HR)、脉搏血氧饱和度(SpO2)、收缩压(SBP)、舒张压(DBP)。根据术中孕妇是否有体动反应,将患者分为体动组和非体动组。结果 本研究中有32.8%的孕妇在术中出现了体动反应。两组的年龄、体重、孕周、人工流产史、生产史、T1与T2的血压、心率和BIS值的差异均无统计学意义(P>0.05)。与无体动组比较,体动组的T1和T2时刻的PI值[分别为(0.39±0.16)、(0.99±0.40)]以及它们的比值[PI(T2/T1)](2.91±1.41)均下降(P<0.05)。应用二分变量logistic回归分析显示T2时的PI和PI(T2/T1)可以独立地预测体动反应。受试者工作曲线分析显示,以T2时的PI预测无体动反应的发生,曲线下面积(areas under curves,AUC)为0.897,以PI(T2/T1)预测无体动反应的发生,AUC为0.857。结论 测量PI值有助于监控患者的麻醉状态,麻醉诱导后的PI以及PI(T2/T1)可能是无痛人工流产术中体动反应的有效预测指标。

关键词: 灌注指数;Masimo set技术;体动反应;异丙酚;人工流产
Abstract:

Objective To investigate the role of the perfusion index (PI) in predicting body movement during indolent induced abortion with intravenous anesthesia by multivariate logistic analysis. Methods 68 early pregnancy women, ASA I, aged 20 y - 30 y, weighed 45 kg - 60 kg, were subjected to indolent induced abortion with 1.8 mg/kg propofol and 0.5 mg/kg ketamine in this study and allocated into moving group and non-moving group based on whether body movement responses occurred during the surgical procedures. The PI, bispectral index (BIS), HR, SpO2 and blood pressure were monitored before induction of anesthesia (T1) and 3 min after induction (T2). Results 32.8% of the pregnant women took place body movement during the procedures. There were no significant difference between two groups in age, weight, gestational weeks, the history of induced abortion or labor, BIS index, blood pressure and HR at T1 and T2 (P>0.05). Compared with non-moving group, the pregnant women in moving group showed lower PI at T1 and T2 (0.39±0.16, 0.99±0.40) and the ratio of PI at T2/T1 (PI(T2/T1)) (2.91±1.41) (P<0.05). Logistic analysis showed that PI at T2 and PI(T2/T1) were independent factors for predicting body movement during the induced abortion. According to the analysis of receivers operating characteristic curve, using PI at T2 and PI(T2/T1) for predicting body movement, the areas under curves (AUC) were respectively 0.897 and 0.857. Conclusions Measurement of PI is helpful for monitoring anesthesia, and PI at T2 as well PI(T2/T1) might be effective in predicting body movement during the induced abortion.

Key words: Perfusion index; Masimo set technology; Body movement; Propofol; Induced abortion