Background Notch signal pathway is one of most important pathways, which plays a key role in cell fate, differentiation, proliferation, survival and development. Recent researches show that notch signal contributes to many pathophysiological process and diseases. Objective To investigate the roles of notch signal pathway in immuno-inflammatory response, and to seek new target regulating immuno-inflammation. Content This article reviews the intimate relationship between notch signal pathway and immuno-inflammatory response, as well as the regulating roles of notch signal in inflammatory diseases. Trend The concrete mechanism of notch signal in various inflammatory diseases including systemic inflammatory response syndrome (SIRS) and sepsis is still unclear, which needs further research.