Abstract: 【Abstract】 Objective To explore the effects of hypertonic sodium chloride hydroxyethyl starch solution(HSH) on the early cerebral vasospasm after clipping of intracranial aneurysm. Methods 20 ASAⅡ-Ⅲ, Hunt and HessⅡ-Ⅲ, Glasgow score 13-14, 20-60-year-old patients undergoing intracranial aneurysm clipping surgery were randomly divided into 2 groups. Group A-HSH infusion group: Patients received 4.2% HSH 6 ml and routine crystalloid-colloid solution intravenously. Group B-Routine solution infusion group. Patients received routine crystalloid-colloid solution intravenously. Total volume of solution infused, intracerebral pressure(ICP), mean arterial pressure(MAP), heart rate(HR), central venous pressure(CVP), hematocrit(HCT) and plasma osmotic pressure(POP) were recorded at different time points during the operation. Right middle cerebral artery blood flow velocity in the two groups was monitored by TCD at the end of operation(T5), 6 h post-operation(T6), 12 h post-operation(T7) and 24 h post-operation(T8), respectively. Results Compared with Group B, CVP in Group A was significantly higher than that in Group B at T6 and T8 (9.4±1.3 vs 7.6±1.0 and 9.4±1.5 vs 7.2±1.6,P<0.05), respectively. ICP in Group A was significantly lower than that in Group B at T5,T6 and T7 (16.5±4.7 vs 21.5±3.6,20.4±3.2 vs 28.2±3.9 and 22.6±3.7 vs 27.4±2.7,P<0.05), respectively. The middle cerebral artery blood velocity in Group A was significantly lower than that in Group B at T6 and T7 (121±15 vs 139±17 and 125±13 vs 137±145,P<0.05), respectively.Conclusion Intravenous infusion of 4.2% HSH 6 ml/kg attenuates the early cerebral vasospasm after clipping of intracranial aneurysm.
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