【Abstract】 Objective To investigate the preemptive analgesia of parecoxib sodium on interleukin-6 and C-reactive protein level in patients undergoing radical excision of breast cancer, and to evaluate its analgesic effect. Methods Sixty ASAⅠ-Ⅱpatients undergoing radical excision of breast cancer were randomly divided into 3 groups (n = 20): preemptive analgesia group (group A), blank control group (B) and postoperative analgesia group (C group), patients of group A and C received intravenous parecoxib sodium 40mg before 10 min or at the end of surgery. Blood samples were collected from the patients before anesthesia induction and 1，6，24 h after surgery for the plasma levels of interleukin-6 and C-reactive protein．Analgesic efficacy was assessed after surgery based on visual analog scales (VAS). Results Compared with the level before the induction of anesthesia，The plasma levels of IL-6 and C-reactive protein were significantly higher than preoperative in three groups at different time points (P <0.01), and increased gradually in group B，and there were very significant difference between the time point of 1 h and 24 h after surgery(P<0．01). Between the two groups: The plasma levels of IL-6 and C-reactive protein of group A were significantly lower than group B and group C (P <0.01 or 0.05), VAS at group A and group C at 1, 2, 4, 6hours were significantly lower than group B (P <0.05), There were no significant differences at 12,24h in three groups. Conclusion Preemptive analgesia with parecoxib can be achieved good analgesic effect and can effectively inhibit the postoperative of IL-6 and C-reactive protein level increased, inflammation and stress response of the regulatory body's immune protective effect to promote postoperative recovery.