【Abstract】Background: Non-steroidal anti-inflammatory drugs (non-steroidal anti-inflammatory drugs, NSAIDs) are a class of drugs with effects of anti-inflammatory, analgesic and antipyretic.It is main by the way of blocking arachidonic acid synthesis of prostaglandins by inhibiting epoxide hydrolase to achieve the effects of antipyretic, analgesic and anti-inflammatory. In recent years, use of NSAIDS with narcotic drugs for perioperative analgesia achieved good clinical result,it particularly widely used in post-operative analgesia.Anastomotic leakage is one of the most serious complications in colorectal surgery.The reports about whether NSAIDs affect colorectal anastomotic healing and increase the incidence of anastomotic leak are different. Content: This review summarizes representative literature NSAIDs colorectal anastomotic healing in humans and experimental animals in recent years. Trend: This review provides a reference for the safe use of NSAIDs and summarizs the impact of NSAIDs on colorectal anastomotic healing mechanism.