Background Protection of pulmonary function during perioperative period is still one of clinical problems, and anesthetists always focus on how to reduce the incidence of pulmonary complications. Sevoflurane as a clinically common anesthetic had proved its protection on pulmonary. Objective To summarize the protection of sevoflurane on pulmonary. Content This article reviews the effect of sevoflurane on different kinds of pulmonary injury, the different dosage methods for pulmonary function and the possible mechanism of the action. Trend This article provides a new angle of management for patients with poor pulmonary function during perioperative period.