【Abstract】 Objective To investigate the effects of hemocoagulase on perioperative blood loss and coagulation in patients with low molecular heparin(LMWH) anticoagulation undergoing total hip replacement(THR). Methods Forty ASA I or II patients aged 60-75 yr scheduled for total hip replacement were randomly divided into two groups( n = 20 each). The forty patients received LMWH for 4000 IU im 1 d preoperatively. 10 min before incision, Group H received hemocoagulase for 2 IU iv and group C received Normal Saline for 5 ml iv. The intraoperative and postoperative 24 h bleeding volume was measured respectively; meanwhile, the coagulation parameters were measured immediately, 24 h after operation respectively. We examined the deep vein thrombosis through CDFI 5 d after operation. Results The intraoperative and postoperative 24 h bleeding volume in Group H were less than Group C (P＜0.05). In both groups, Hb, RBC, Hct immediately and 24 h after operation were significantly lower than preoperation (P＜0.05). In both groups, APTT, PT, Fib immediately and 24 h after operation were same to preoperation (P＞0.05).In both groups, there was no difference in the rate of deep venous thrombosis(P＞0.05). Conclusion Perioperative bleeding volume can be reduced by intravenous injecting hemocoagulase preoperatively, and the coagulation can not be influenced.