国际麻醉学与复苏杂志   2013, Issue (10): 4-4
    
氨甲环酸在非体外循环冠状动脉搭桥术的应用进展
孙加晓1()
1.哈尔滨医科大学附属第一临床医学院麻醉科
The progress of application of tranexamic acid in off-pump coronary artery bypass surgery
 全文:
摘要：

背景　近年来，伴随着医学的快速发展，非体外循环冠状动脉搭桥术（off-pump coronary artery bypass， OPCAB）的应用逐渐增多，氨甲环酸（tranexamic acid， TA）作为抗纤溶药物在OPCAB中的作用倍受关注。　目的　探讨TA在OPCAB中的应用，为临床实践提供科学参考。　内容　综述TA的作用机制及其在OPCAB中的应用进展。　趋向　使TA更加安全、有效地应用于OPCAB中。
关键词： 氨甲环酸；非体外循环冠状动脉搭桥术；抗纤溶；血小板保护；减少输血；促凝
Abstract:

Background　With rapid development of medical science， tranexamic acid（TA） has received more and more attention as a antifibrinolytic drug in off-pump coronary artery bypass（OPCAB） surgery in recent years.　Objective　To investigate the application of TA in OPCAB surgery and to provide scientific reference for clinical practice.　Content　To summerize the mechanism and its clinical application of TA in OPCAB surgery.　Trend　To promote a safer and more effective application of TA in OPCAB surgery.
Key words: Tranexamic acid; Off-pump coronary artery bypass; Antifibrinolytic; Platelet protection; Reduce blood transfusion; procoagulant