Background Parecoxib sodium, the first injection preparation of selective cyclooxygenase-2 inhibitors ,acts with anti-inflammatory, analgesic and organ protective properties , it has been used in clinical extensively in present．Purpose To review the research status of its organ protective effects and provide guidance for studying the reasonable application of the drug in this field．Content In this review , we summarized the organ protective effects and safety of parecoxib . Trend Parecoxib has wide application foreground in clinical.