Background Endotoxic shock is one of clinical devastating symptom in common, which lead to the protopathy more serious and complexed. It has been paid more attention in the field of medicine because of its feral, rapid progress and high mortality. Objective This review summarized the therapeutic effect of electro-acupuncture in endotoxic shock. Content Electro-acupuncture plays an important role of stabling cycle, improving blood pressure, adjusting humoral factors and protecting important organs in endotoxic shock by inhibiting tumor necrosis factor (TNF), interleukin-6 (IL-6), nitric oxide and oxygen free radical and so on. Trend The pathogenesis of endotoxic shock are complicated, and electro-acupuncture may be applied to remedy for endotoxic shock and the damage of important organs by mobilizing endogenous protective system and the related signal transduction pathways.