国际麻醉学与复苏杂志   2013, Issue (12): 10-10
    
缝隙连接蛋白Cx43与心肌缺血再灌注损伤机制的研究进展
韩霜, 容俊芳1()
1.河北省人民医院
The progress of the gap junctional connexin 43 and myocardial ischemia reperfusion injury mechanism
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摘要：

[摘要] 背景 研究表明，心肌缺血再灌注(I/R)损伤的发病机制与氧自由基过量产生、钙超载、线粒体损伤及心肌细胞凋亡等密切相关，最新研究发现缝隙连接也参与心肌缺血再灌注损伤。目的 本文主要针对缝隙链接蛋白Cx43与心肌缺血再灌注损伤的关系做一综述。内容Cx43在心肌缺血再灌注损伤中参与心肌保护作用，其机制可能与钙超载、在线粒体中的分布及细胞凋亡等因素相关。趋向 未来研究需要进一步探究Cx43与心肌细胞凋亡之间的关系，同时为临床实际工作提供依据。
关键词： Connexin 43,缝隙接合部,心肌再灌注损伤
Abstract:

【Abstract】 Background The mechanism of myocardial ischemia reperfusion connect with peroxidation, calcium overload, mitochondria injury, myocardial cells apoptosis and so on. Recently the sdudy indicate that the gap junctional intercellular communication of myocardial cells are be concerned with myocardial ischemia reperfusion injury. Objective This article summarized the relationship of the gap junctional connexin 43 of myocardial cells with myocardial ischemia reperfusion injury. Content Connexin 43 could be protected myocardial during myocardial ischemia reperfusion injury. The mechanism may be related with calcium overload, mitochondria injury, myocardial cells apoptosis and so on. Trend Researches in future should be taken to further explore of the relation between Cx43 and apoptosis, and strengthen the cilinial applications．
Key words: Connexin 43，Gap Junctions, myocardial reperfusion injury