国际麻醉学与复苏杂志   2014, Issue (1): 0-0
    
T细胞免疫球蛋白及黏蛋白域蛋白4在免疫反应与疾病中的作用
于雄伟, 薄禄龙, 邓小明1()
1.上海市长海医院麻醉科
Role of TIM4 in Immune Response and Disease
 全文:
摘要：

背景 T细胞免疫球蛋白及黏蛋白域蛋白(T cell immunoglobulin domain and mucin domain，TIM)家族能调节T细胞免疫反应。T细胞免疫球蛋白及黏蛋白域蛋白4(T cell immunoglobulin domain and mucin domain 4，TIM4)只表达在抗原递呈细胞表面。作为T细胞活化强有力的免疫共刺激分子，调控Th细胞的分化增殖。目的 研究TIM4与其配体结合后调节T细胞免疫反应的机制，探究TIM4在疾病中的作用。内容 TIM4的基础研究进展，TIM4在疾病中的研究进展。趋向 TIM4对T细胞增殖的促进或抑制作用取决于其结合的配体和T细胞分化的程度。TIM4的表达异常与多种过敏性或自身免疫性疾病的发生有关，可能成为药物治疗的新靶点。
关键词： T细胞免疫球蛋白及黏蛋白域蛋白4；Th细胞活化；抗原递呈细胞；过敏反应；免疫耐受
Abstract:

Background T cell immunoglobulin domain and mucin domain (TIM) molecules can regulate T cell immune responses. TIM4 is exclusively expressed in APCs. As a strong immune costimulatory molecule in T cell activation, it can regulate Th cell proliferation and differentiation. Objective Clarify the mechanism of T cell immune response regulated by TIM4 and its ligands, and explore the role of TIM4 in disease. Content To review the recent advance of TIM4 molecule and the role of TIM4 in diseases. Trend The role of TIM4 in T cell proliferation and inhibition depend on its ligand and the stage of T cell differentiation. TIM4 regulated immune responses are associated with many kinds of diseases，making TIM4 a new target for therapy．
Key words: TIM4; Th cell activation; APCs; anaphylaxis; immune tolerance