Objective To investigate the effect of propofol on postoperative mood for women with artificial abortion.　Methods　One hundred and twenty cases of unmarried women scheduled for artificial abortion were randomly divided into two groups： propofol（group P） or etomidate （group E） in combination with sufentanil. The mood of women was evaluated preoperatively and postoperatively by the positive and negative affect scale（PANAS）. PANAS is composed of 20 adjectives， describing 10 of positive emotions and negative emotions， each of which has five answers， counted 1， 2， 3， 4， 5， respectively. Adverse reactions such as dreams， dizziness， abdominal pain and vomiting were recorded postoperatively.　Results　There were no significant differences in loss of consciousness time， awakening time， blood pressure， heart rate， the score of positive emotions， and the score of negative emotions between two groups preoperatively. After anesthesia， blood pressure and heart rate were lower in the group P than the group E［（74±12） mmHg vs（79±13） mmHg（1 mmHg=0.133 kPa）， （69±16） bpm vs （74±17） bpm， P<0.05］. Lower negative emotions scores postoperatively was found compared to that preoperatively in the group P and group E［（24±9） vs （31±7），（25±7） vs （30±8）， P<0.05］respevtively. The score of positive emotions postoperatively was increased in the group P compared to that preoperatively［（25±7） vs（34±8）， P<0.05］， but no changes in the group E. No significance differences in the incidence of postoperative dizziness， nausea and abdominal pain was found between two groups. The incidence of dreams was 36.7% in the group P， and 13.3% in the group E.　Conclusions　Women anesthetized with propofol for artificial abortion were more likely to induce positive emotions postoperatively. The change of the mood is independent of its quick action of propofol and low incidence of dizziness and nausea.