Abstract: Background Dexmedetomidine(Dex) is a highly selective α2 adrenoreceptor(α2AR) agonist acting with analgesia, sedation, anxiolysis and sympatholysis. Animal studies have validated the safety of intrathecal Dex. Objective To review the progress of clinical application of intrathecal Dex and to provide further guidance for its clinical application. Content The article discusses the safety of intrathecal Dex and the influence of local anesthetic effect, antinociption, sedation and hemodynamics. Trend Intrathecal Dex can make up for deficiencies in the traditional spinal block and has a promising future.
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