国际麻醉学与复苏杂志   2014, Issue (7): 8-8
    
胰高血糖素样肽-1及其类似物保护认知功能的研究进展
张亮, 闵苏1()
1.重庆医科大学附属第一医院
Protective effects of glucagon-like peptide-1 and its analogs on cognitive function
 全文:
摘要：

背景 认知功能障碍是指学习记忆、思维判断等大脑高级功能异常，目前尚无确切的防治药物。2型糖尿病被公认为发生认知功能障碍的危险因素。胰高血糖素样肽-1（glucagon-like peptide-1，GLP-1）及其类似物是一种针对2型糖尿病的新型降糖药，研究发现其还具有保护认知功能的作用。 目的 为GLP-1及其类似物应用于临床防治认知功能障碍提供理论依据。内容 就GLP-1及其类似物的保护认知功能的研究现状作一综述。 趋向 有望成为防治认知功能障碍等神经病理性疾病的新型药物。
关键词： 类似物；认知功能；胰高血糖素样肽-1
Abstract:

Background Cognitive dysfunction is defined as learning, memory, thinking, judgment and other higher brain dysfunction. There is no definitive prevention drugs. Type 2 diabetes mellitus (T2DM) is recognized as one risk factor for cognitive dysfunction. Glucagon-like peptide -1 (GLP-1) and its analogues, a class of antidiabetic agents, have the protective effects on cognitive function. Objective To provide the theoretical basis for the prevention and treatment of GLP-1 and its analogues on cognitive dysfunction . Content This review will focus on protective effects of GLP-1 and its analogs on cognitive function Trend GLP-1 and its analogs are expected to become new drugs for prevention and treatment of neuropathic diseases such as cognitive dysfunction.
Key words: Analogue; cognitive function; Glucagon-like peptide -1