Objective: To observe preventive effects of Parecoxib sodium on occurring of emergence agitation during the recovery period of general anesthesia for the patients who underwent epigastric surgeries. Methods: 120 patients, ASA I～Ⅱ, underwent elective epigastic surgeries were divided randomly into four groups, 30 cases in each group. Anesthesia of all patients was maintained with sevoflurance and remifentanil, keeping the BIS around 40-50. Parecocib 0.8mg/kg was intravenously infused into the patients just before anesthesia induction in group A and just before the closure of peritoneum in group B; sufentanil 0.08μg/kg was injected just before the closure of peritoneum in group C, 2ml saline as placebo was administrated in group D. The level of agitation (RS),VAS and sedation (RSS) were evaluated during the recovery period of general anesthesia. MAP and HR were monitored at pre-induction (T1), 10 min before tracheal extubation (T2), immediately after tracheal extubation(T3)and 10 min after tracheal extubation ( T4). Results: MAP and HR in group D were significantly higher than those in group A, B,C at T3,T4(P<0.05); RS score in group A,C is significantly lower than those in group B,D(P<0.05); requirement of remifentanil in group A is lower than that in others group(P<0.05); score of RSS in group C is much lower than other groups significantly (P<0.05), and incidence of nausea and vomiting is higher than other groups significantly (P<0.05). Conclusion: Parecoxib sodium has a good preemptive analgesic effect for the patients of epigastric surgeries, preventing the incidence of postoperative agitation and adverse reactions during the recovery period of general anesthesia. Key words: Parecoxib; agitation; sufentanil; general anesthesia