【Ａｂｓｔｒａｃｔ】　Ｏｂｊｅｃｔｉｖｅ　To investigate the effects of peri-operative esmolol for patients undergoing laparoscopic radical hysterectomy of cervical cancer on remifentanil-induced hyperalgesia.　Methods　Fifty patients American Society of Anesthesiology （ASA） Ⅰ-Ⅱ undergoing laparoscopic radical hysterectomy of cervical cancer were randomly assigned by a table of random numbers to two groups（n=25）. Before the induction of anesthesia， the group esmolol （group Ⅰ）， patients were administered 0.5 mg/kg esmolol， 10 μg·kg-1·min-1 maintained to extubation， and the group control （group Ⅱ） patients received normal saline of the same volume. Anesthesia was induced with remifentanil 2 μg/kg， midazolam 0.05 mg/kg， etomidate 0.2 mg/kg， rocuronium 0.6 mg/kg， maintained with propofol 3 mg·kg?蛳1·h?蛳1?蛳6 mg·kg?蛳1·h?蛳1 and remifentanil 0.15 μg·kg?蛳1·min?蛳1?蛳0.5 μg·kg?蛳1·min?蛳1，cisatracurium besilate for injection 0.1 mg·kg?蛳1·h?蛳1 in both groups. Thirty minutes before the expected end of surgery， 1 μg/kg Fentanyl was administered intravenously. At the end of surgery， patients received fentanyl patient controlled intravenous analgesia（PCIA）. Peri-incisional pain thresholds were measured for baseline values before operation， at 24 h and 48 h repeated postoperatively. Pain thresholds were established by an detecting meter for pain threshold. The visual analogue scale （VAS） was assessed at 30 min， 6， 24 h after surgery. Total fentanyl consumption was recorded for 24 h and 48 h after surgery.　Results　peri-incision region pressure pain thresholds were obviously higher at 24 h ［（3.21±0.23） kg/cm2］ and 48 h ［（3.18±0.19） kg/cm2］ postoperatively in group Ⅰ than group Ⅱ ［（2.69±0.21）， （2.62±0.20） kg/cm2］ （P<0.05）. In group Ⅰ， pain thresholds were higher at 24 h ［（3.21±0.23） kg/cm2］ and 48 h ［（3.18±0.19） kg/cm2］ postoperatively compared with preoperative baseline values ［（2.93±0.17） kg/cm2］（P<0.05）. Pain thresholds in group Ⅱ at 24 h ［（2.69±0.21） kg/cm2］ and 48 h［（2.62±0.20） kg/cm2］ postoperatively were lower compared with preoperative baseline values ［（2.91±0.18） kg/cm2］. In group I， the VAS scores at 30 min ［（4.56±1.36） score］， 6 h ［（3.64±1.32） score］ and 24 h［（2.52±1.08） score］ postoperatively were significantly lower compared with group Ⅱ［（5.84±1.70）， （4.68±1.41）， （3.20±1.12） score］ at all evaluation times（P<0.05）. The fentanyl consumption was lower at 24 h［（0.53±0.03） mg］ and 48 h ［（1.09±0.09） mg］ postoperatively compared with group Ⅱ［（0.55±0.04）， （1.15±0.08） mg］ （P<0.05）.　Conclusions　Peri-operative esmolol for patients undergoing laparoscopic radical hysterectomy of cervical cancer may attenuate remifentanil-induced hyperalgesia and reduce the required dosage of the postoperative fentanyl.