【Abstract】 Objective To study the effect of self-made sound light pipe core in patients with difficult airway. Methods 42 patients with difficult airway scheduled for endotracheal intubation were randomly divided into two groups, 21 cases in each group. Self-made microphone light wand was used in group I, while laryngoscope was used in group II. Hemodynamic changes were evaluated, and the first successful rate of intubation, the time of intubation and the complications of intubation were observed in all patients. Results There were no difference between two groups in age, sex and weight (P>0.05). Compared with group II, the first successful rate of intubation, the time of intubation, the complications of intubation in group I were better (P <0.05). Conclusions Self-made sound light pipe core is relatively safe, effective and promising in patients with difficult airway.