国际麻醉学与复苏杂志   2014, Issue (10): 10-10
    
右美托咪定对小儿扁桃体和/或腺样体术后躁动的影响
张晔, 席宏杰1()
1.黑龙江哈尔滨医科大学附属肿瘤医院麻醉科
The effect of low dose dexmedetomidine on emergence agitation after adenotossillec-tomy and/or adenoidectomy in children by sevoflurane anesthesia
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摘要:

目的 观察小剂量右美托咪定(dexmedetomidine, Dex)对小儿七氟烷全麻扁桃体和/或腺样体术后苏醒期躁动的影响。 方法 选取年龄2岁~8岁,美国麻醉医师协会(ASA)分级Ⅰ~Ⅱ级,拟在七氟烷吸入麻醉下进行扁桃体和/或腺样体摘除的患儿90名,采用双盲法以抽签形式将患者随机分为两组(每组45例):实验组(D组)和对照组(S组)。D组在诱导时给予Dex负荷量0.3 μg/kg(10 min泵入),后以0.2 μg·kg-1·h-1维持;S组给予等容生理盐水,两组麻醉均以七氟烷维持,记录患者心率(heart rate, HR)、血压、脉搏血氧饱和度、呼气末七氟烷浓度、停药到自主呼吸恢复时间、停药至拔管时间、拔管后躁动评分。 结果 D组苏醒期躁动发生率为28.89%,S组为64.44%,且每个时间记录点D组发生躁动的人数均少于S组。 结论 小剂量Dex能减轻小儿七氟烷全麻扁桃体和/或腺样体术后苏醒期躁动。

关键词: 右美托咪定; 七氟烷; 扁桃体切除; 腺样体切除; 小儿; 术后躁动
Abstract:

Objective To observe the effect of low dose dexmedetomidine on emergence agitation after tonsillectomy and/or adenoidectomy in children with sevoflurane anesthesia. Methods Ninety children, aged 2 y-8 y, ASAⅠ-Ⅱ, undergoing adenotonsillectomy and/or Adenoidectomy, were randomly divided into two groups: the dexmedetomidine group(D group, n=45) and the saline group(S group, n=45). Anesthesia was maintained with sevoflurane and oxygen. D group patients were given dexmedetomidine 0.3 μg/kg (in 10 min) and maintained with 0.2 μg·kg-1·h-1. The S group was given the same dosage saline. Intraoperative hemodynamics were recorded every 5 min. Time of spontaneous breathing, time of extubation, and the emergence agitation in PACU were recorded. Results The incidence of emergence agitation was 28.89% in group D, and 64.44 % in group S, the mean agitation scores in the D group were lower than the S group except at 10 min. Conclusions So low dose dexmedetomidine could reduce the emergence agitation in children receiving sevoflurane undergoing tonsillectomy and/or adenoidectomy.

Key words: Dexmedetomidine; Sevoflurane; Adenotosillectomy; Adenoidectomy; Children; Emergence agitation