国际麻醉学与复苏杂志   2014, Issue (12): 1-1
    
缺血预处理在肝脏缺血/再灌注损伤方向的临床应用
陈莎莎, 孔海莹, 温小红1()
1.浙江大学附属第一医院
The effect of ischemic preconditioning on ischemia/reperfusion injury in liver: a review from bench to bedside
 全文:
摘要:

背景 在肝脏移植术及肝脏切除等相关手术中,肝脏缺血/再灌注损伤(ischemia/reperfusion injury, I/RI)影响手术的成败、术后患者肝脏功能的恢复、患者生存率及生存质量。很多相关的实验研究I/RI的发生发展机制、寻求解决或缓解该损伤的有效干预措施。 目的 综述国内外缺血预处理(ischemic preconditioning, IPC)在肝脏手术中的实验研究与临床应用,为预防肝脏I/RI提供临床新思维。 内容 就近5年关于肝脏IPC及远端缺血预处理(remote ischemic preconditioning, RIPC)对肝脏I/RI的保护作用进行阐述。 趋向 随着对肝脏IPC机制及临床应用的不断研究,将对其今后的发展提供更全面的依据。

关键词: 肝脏; 缺血预处理; 实验; 临床研究
Abstract:

Background Ischemia/reperfusion injury (I/RI) plays an important role in many liver surgeries, such as liver transplantation and hepatectomy. Much work has been done investigating the mechanism of I/RI and the therapies to alleviate the I/RI. Objective This review aims to provide new insights into preventing hepatic I/RI by summarizing the research actuality involved in hepatic ischemic preconditioning (IPC). Content We reviewed the two protective methods including IPC and remote ischemic preconditioning (RIPC) investigated in the latest five years. Trend The protective mechanism of ischemic preconditioning in liver should be deeply clarified to provide enough proof for clinical application.

Key words: Liver; Ischemic preconditioning; Laboratory; Clinical application