Objective: To investigatethe effect of combination therapy of nerve block and acupuncture to phantom limb pain of upper extremity after amputation . Methods 80 patients with phantom limb pain of upper limb were randomly divided into four groups (n=20),20 patients received basic treatment (A group ),basic treatment included Medications and Psychotherapy ; 20 patients recieved acupuncture and basic treatment (B group) ; 20 patients recieved nerve block and basic treatment (C group ) ; 20 patients recieved nerve block、 acupuncture and basic treatment (D group ) . Scores of VAS 、 SR-36 and comprehensive comparison of efficacy were used to assess before and after treatment,and respectively Compared between before treatment and after treatment , or among the four groups . Results VAS scores and SF-36 scores of four groups of patients were significant differences after treatment compared with before treatment(P <0.05), VAS scores decreased after treatment , SF-36 scores were significantly increased ; compared with A group, VAS scores of B group、C group and D after treatment decreased significantly,and the differences were statistically significant (P <0.05); compared with B group and C group , VAS scores decreased of D group decreased significantly after treatment,and SF-36 scores were significantly increased ,the difference was statistically significant (P <0.05). Comprehensive comparison of efficacy of four groups of patients : After treat for 5 weeks, compared with the A, there was significant difference in comprehensive comparison of efficacy of B group、C group and D (P <0.05),this means that the treatment effect of B group、C group and D group is better than A group, the treatment effect of D group is best among four groups . Conclusion The use of basic drug and psychology therapy combined with sympathetic blockade therapy and acupuncture treatment can significantly improve the treatment effect of phantom limb pain of upper limb after amputation, improve the patient's quality of life.