国际麻醉学与复苏杂志   2015, Issue (1): 7-7
    
尼克酰胺磷酸核糖转移酶对心肌缺血/再灌注的影响研究进展
吴倩, 刘新伟1()
1.重庆医科大学
The research advance of the potential role of nicotinamide phosphoribosyltransferase in myocardial ischemic/reperfusion injury
 全文:
摘要：

背景　尼克酰胺磷酸核糖转移酶（nicotinamide phosphoribosyltransferase， NAMPT）是合成烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide， NAD）的限速酶。NAMPT可存在于细胞内和细胞外，它们的作用不尽相同。NAMPT在心血管系统中发挥着重要作用，但在心肌缺血/再灌注（ischemia/reperfusion， I/R）中的作用尚存争议。　目的　进一步了解NAMPT的心血管作用及对心肌I/R的影响。　内容　就目前研究对NAMPT的来源及潜在的心血管作用、细胞内NAMPT（intracellular NAMPT， iNAMPT）及细胞外NAMPT（extracellular NAMPT， eNAMPT）、以及对心肌I/R的影响作一综述。　趋向　促进对NAMPT的作用及机制的了解，NAMPT有望成为治疗心肌I/R损伤的新靶点。
关键词： 尼克酰胺核糖转移酶；　缺血/再灌注；　心肌；　沉默信息调节因子2相关酶家族
Abstract:

Background　Nicotinamide phosphoribosyltransferas（NAMPT） is a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide（NAD）. NAMPT can exist within and outside cells， and their effects are not the same. NAMPT plays an important role in cardiovascular system， but the role of NAMPT in myocardial ischemic reperfusion is still controversial.　Objective　To further understand the role of NAMPT in cardiovascular system and myocardial ischemic/reperfusion（I/R）.　Content　Review the current researches on the souces of NAMPT and the potential cardiovascular effects， the effects of intracellular NAMPT（iNAMPT） and extracellular NAMPT（eNAMPT） on myocardial ischemic reperfusion.　Trend　Promote the understanding the role and mechanisms of NAMPT. It is expected to become a new target for the treatment of myocardial I/R injury.
Key words: Nicotinamide phosphoribosyltransferase；　Ischemic/reperfusion；　Myocardial；　Silent information regulator 2 related enzymes