【Ａｂｓｔｒａｃｔ】　Ｏｂｊｅｃｔｉｖｅ　To investigate clinical effects of stellate ganglion block（SGB） combined with drug therapy on gastric ulcer.　Methods　Eighty cases of Helicobacter pylori infection and endoscopic diagnosis of gastric ulcer were randomly divided into two groups （n=40）： observation group and control group. The control group received amoxicillin 500 mg， 3 times/d， omeprazole 20 mg， 1 times/d， clarithromycin 250 mg， 2 times/d， observation group received SGB combined with drug therapy and the drug type and dosage is the same as control group.　Results　The cure rate of patients in the observation group is 60% and total efficiency is 100%， the cure rate of patients in the control group is 50% and total efficiency is 90%， there was significant difference in the clinical effects of two group （P<0.05）， compared with control group， gastric ulcer patients of observation group have higher cure rate and total efficienc. The improvement rate of mucosal inflammation after treatment in patients of observation group is 100% and the relapse rate of mucosal inflammation is 5%， the improvement rate of mucosal inflammation after treatment in patients of control group is 92.5% and the relapse rate of mucosal inflammation is 15%， there was significant difference in the clinical effects of two group（P<0.05）， compared with control group， gastric ulcer patients of observation group have higher cure efficiency. Helicobacter pylori （H.pylori） clearance rate of patients is 90% in observation group after treatment and H.pylori clearance rate is 75% after treatment in control group， there was significant difference in the clinical effects of two group （P<0.05）， compared with control group， gastric ulcer patients of observation group have higher H.pylori clearance rate.　Conclusions　SGB combined with drug therapy can improve gastric ulcer treatment.