Ｏｂｊｅｃｔｉｖｅ　To evaluate the gender differences in dose-response curve of vecuronium in epilepsy patients and provide a reference for its individualized application.　Methods　Hundred ASA grade Ⅰ-Ⅱ epilepsy patients were enrolled in this study. All patients were divided into male group（group M） and female group（group F）（n=50）， they recieved the method of single dose injection under midazolam-fentanyl intravenous anesthesia. Every patient received intravenous single bolus of 20， 30， 40， 50， 60 μg/kg of vecuronium respectively（n=10）. The neuromuscular block was measured by neuromuscular transmission monitor and the responses were defined in terms of the percentages of maximum suppression in T1 of train of four stimulation（TOF） of the adductor pollicis muscle. According to log-probit transformation of the data of dose and response， the dose-response curve of vecuronium was established through linear regression. The onset time of vecuronium was also observed.　Results　The 50% effective dose（ED50），７５% effective dose（ED75）， ９０% effective dose（ED90）， ９５% effective dose（ED95） values of vecuronium in male epilepsy patients were（31±6），（40±8），（50±9），（57±7） μg/kg. The ED50， ED75， ED90， ED95 values of vecuronium in female epilepsy patients were（31±6），（40±7），（50±9），（58±9） μg/kg. No significant difference in onset time was observed among 5 dose groups（P>0.05）.　Conclusions　There was no gender difference in dose-response curve of vecuronium in epilepsy patients.