国际麻醉学与复苏杂志   2015, Issue (6): 4-4
    
急性肺损伤的干细胞治疗研究进展
黄小聪, 薛庆华1()
1.阜外心血管病医院麻醉科
Research progress of stem cell therapy for acute lung injury
 全文:
摘要:

背景 保护性肺通气治疗可降低急性肺损伤(acute lung injury, ALI)及急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)的病死率,但因损伤的肺组织未得到及时修复,其病死率仍居高不下。 目的 审视干细胞疗法对ALI或ARDS的疗效。 内容 阐述间充质干细胞(mesenchymal stem cell, MSC)、胚胎干细胞(embryonic stem cell, ESC)、诱导多能干细胞、内皮祖细胞及内源性肺干细胞治疗ALI的研究进展。 趋向  MSC由于细胞来源广泛、易于分离和增殖、实验证据丰富而最具临床转化前景。

关键词: 急性肺损伤;干细胞;间充质干细胞;再生
Abstract:

Background The mortality of acute lung injury(ALI) and acute respiratory distress syndrome (ARDS) has been reduced by the introduction of lung-protective ventilation, but it remains high due to delayed repair of injured lung tissue. Objective Researches are carried out to examine the effectiveness of stem cell therapy on ALI or ARDS. Content This review elaborated the research progress of mesenchymal stem cell(MSC), embryonic stem cells(ESC), induced pluripotent stem cells, endothelial progenitor cells and endogenous lung stem cells in the treatment of ALI and ARDS. Trend MSCs are considered to be most promising stem cells for clinical translation due to its rich source, easy isolation and proliferation, and abundant of experimental evidences. 【Key words】

Key words: Acute lung injury; Stem cell; Mesenchymal stem cell; Regeneration