Abstract: Background Neuropathic pain(NP) is one of the most common and tricky chronic pain. Janus kinases-signal transducer and activators of transcription(JAKs-STATs) signaling pathway is an important signaling pathway in mediating cell reaction system. In recent years, studies have shown that JAKs-STATs signaling pathway is closely related to NP. Objective To explore the mechanisms of JAKs-STATs signaling pathway in NP. Content This article firstly reviewed the biological characteristics of JAKs-STATs signaling pathway; then reviewed the current studies about the regulating mechanism of JAKs-STATs signaling pathway in NP. Trend It provides a new theory basis for the treatment of NP.
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